This product is a SU-DHL-4 B cell engineering tool based on the Gold nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (SHS-229-sgRNA-Cpf1-RS-1 ) genome editor.
| Host Cell | SU-DHL-4 |
| Target | CD24 |
| Insert Clone | ZHB-pA12 |
| Safe Harbor Sites (SHS) | SHS-229 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Mouse genome E-7 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | Thymoquinone |
| Particle Size | <500 |
| Charge (mv) | −25 to -125 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colorectal cancer; Breast cancer; Lung cancer; Esophageal squamous cell carcinoma; Bladder cancer |
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