This product is a NCI-H929 [H929] B cell engineering tool based on the Niosomes (Anti-EGFR mAb/Epidermal GrowthFactor Receptor) delivery system and CRISPR-based (CCR5-tracr RNA-SpCas9-Brefeldin A ) genome editor.
| Host Cell | NCI-H929 [H929] |
| Target | CD26 |
| Insert Clone | 5B20 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | tracr RNA |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Niosomes |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | Thymoquinone |
| Particle Size | <2500 |
| Charge (mv) | −2 to -30 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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