This product is a Raji B cell engineering tool based on the Gold nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (hROSA26-huIgH296-Cpf1-L755507 ) genome editor.
| Host Cell | Raji |
| Target | CD26 |
| Insert Clone | 4B7R |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | Cpf1 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Celastrol |
| Particle Size | 20-3500 |
| Charge (mv) | 0 to -16 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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