This product is a Raji-Luc2 B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (SHS-289-crRNA:tracrRNA duplex-Cas12-RS-1 ) genome editor.
| Host Cell | Raji-Luc2 |
| Target | CD276 |
| Insert Clone | 10A7 |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Mouse genome E-1 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <1000 |
| Charge (mv) | −11 to -345 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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