This product is a Ramos (RA 1) B cell engineering tool based on the Sphingosomes (EpCAM aptamer/Epithelial celladhesion molecule) delivery system and CRISPR-based (AAVS1-SpCas9-NLS-Cas9-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CD276 |
| Insert Clone | MAb-A |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Sphingosomes |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Celastrol |
| Particle Size | 20-3500 |
| Charge (mv) | −15 to -185 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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