This product is a Farage B cell engineering tool based on the Nanoparticles (EpCAM aptamer/Epithelial celladhesion molecule) delivery system and CRISPR-based (CCR5-sgRNA-Cpf1-3'-Azido-3'-deoxythymidine ) genome editor.
| Host Cell | Farage |
| Target | CD276 |
| Insert Clone | 11A7 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genomeD-4(2) |
| Vehicles | Nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Celastrol |
| Particle Size | 20-3500 |
| Charge (mv) | 0 to -30 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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