This product is a HS-Sultan B cell engineering tool based on the Nanoparticles (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (AAVS1-sgRNA-SpCas9-Nocodazole ) genome editor.
| Host Cell | HS-Sultan |
| Target | CD276 |
| Insert Clone | 7-8H7-8 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | SpCas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | DOX |
| Particle Size | 10-500 |
| Charge (mv) | 8-55 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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