This product is a Jiyoye [Jijoye, P-2003, P-3J] B cell engineering tool based on the Sphingosomes (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-sgRNA-Cpf1-L755507 ) genome editor.
| Host Cell | Jiyoye [Jijoye, P-2003, P-3J] |
| Target | CD276 |
| Insert Clone | IFH:F999:IF33 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-2 |
| Vehicles | Sphingosomes |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Celastrol |
| Particle Size | 20-3500 |
| Charge (mv) | −10 to -50 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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