This product is a Toledo B cell engineering tool based on the Solid lipid nanoparticles (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (SHS-229-tracr RNA-SpCas9-RS-1 ) genome editor.
| Host Cell | Toledo |
| Target | CD47 |
| Insert Clone | 3.3F33 |
| Safe Harbor Sites (SHS) | SHS-229 |
| gRNA | tracr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | DOX |
| Particle Size | 10-500 |
| Charge (mv) | <-1 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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