This product is a Raji B cell engineering tool based on the Solid lipid nanoparticles (Transferrin/Transferrin receptor) delivery system and CRISPR-based (SHS-255-SpCas9-NLS-Cas9-RS-1 ) genome editor.
| Host Cell | Raji |
| Target | CD7 |
| Insert Clone | 3F3e |
| Safe Harbor Sites (SHS) | SHS-255 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | DOX |
| Particle Size | ≤10000 |
| Charge (mv) | −3 to -77 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Breast cancer; Lung cancer; Pancreatic cancer |
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