This product is a DG-75 [D.G.-75] B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-crRNA:tracrRNA duplex-Cas12-RS-1 ) genome editor.
| Host Cell | DG-75 [D.G.-75] |
| Target | CDH1 |
| Insert Clone | BCWJC-1785 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genomeD-4(2) |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | ESC8 |
| Particle Size | 20-150 |
| Charge (mv) | −25 to -47 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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