This product is a Raji-Luc2 B cell engineering tool based on the Quantum dots (Mannose/Mannose receptor) delivery system and CRISPR-based (CCR5-huIgH296-SpCas9-Nocodazole ) genome editor.
| Host Cell | Raji-Luc2 |
| Target | CDH1 |
| Insert Clone | BCXC-1502 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Quantum dots |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <100 |
| Charge (mv) | −3 to -77 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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