This product is a GA-10 (Clone 4) B cell engineering tool based on the Magnetic nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (hROSA26-huIgH296-Cas9-(Z)-4-Hydroxytamoxifen ) genome editor.
| Host Cell | GA-10 (Clone 4) |
| Target | CDKN2A |
| Insert Clone | BCRYC-1636 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Mouse genome E-8 |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <500 |
| Charge (mv) | <-25 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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