This product is a GA-10 B cell engineering tool based on the Nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (SHS-323-crRNA:tracrRNA duplex-Cas12-SCR7 pyrazine ) genome editor.
| Host Cell | GA-10 |
| Target | CDKN2A |
| Insert Clone | BCWJC-1911 |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <1000 |
| Charge (mv) | −2 to -30 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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