This product is a NCI-H929 [H929] B cell engineering tool based on the Gold nanoparticles (Anti-EGFR mAb/Epidermal GrowthFactor Receptor) delivery system and CRISPR-based (CCR5-huIgH296-Cas9-Brefeldin A ) genome editor.
| Host Cell | NCI-H929 [H929] |
| Target | CDKN2A |
| Insert Clone | BCWJC-1908 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | huIgH296 |
| Nuclease | Cas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Mouse genome E-1 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 20-3500 |
| Charge (mv) | ≤50 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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