This product is a CA46 B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (hROSA26-SpCas9-SpCas9-Brefeldin A) genome editor.
| Host Cell | CA46 |
| Target | EIF2S1 |
| Insert Clone | BCGR-0659CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | SpCas9 |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | <1660 |
| Charge (mv) | 10 to 100 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Non-small cell lung cancer; Prostate cancer; Liver cancer |
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