This product is a SU-DHL-4 B cell engineering tool based on the Dendrimers (EpCAM aptamer/Epithelial cell adhesion molecule) delivery system and CRISPR-based (AAVS1-tracr RNA-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | SU-DHL-4 |
| Target | EIF2S1 |
| Insert Clone | PEIF2S1ATCR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Dendrimers |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <100 |
| Charge (mv) | -5 to -40 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Non-small cell lung cancer; Prostate cancer; Liver cancer |
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