This product is a ST486 B cell engineering tool based on the Nanoparticles (Transferrin/Transferrin receptor) delivery system and CRISPR-based (CCR5-crispr RNA-SpCas9-Brefeldin A) genome editor.
| Host Cell | ST486 |
| Target | EN1 |
| Insert Clone | 3H2-CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | ≤900 |
| Charge (mv) | 10 to 100 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Colorectal cancer; Prostate cancer |
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