This product is a Raji B cell engineering tool based on the Solid lipid nanoparticles (N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin) delivery system and CRISPR-based (hROSA26-crRNA:tracrRNA duplex-Cas12-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | Raji |
| Target | EN1 |
| Insert Clone | Y26CCR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin |
| Active Agents | DOX |
| Particle Size | 1-100 |
| Charge (mv) | 10 to 45 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Colorectal cancer; Prostate cancer |
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