This product is a DG-75 [D.G.-75] B cell engineering tool based on the Magnetic nanoparticles (Tumor-homing peptide tLyp-1/NRP-1) delivery system and CRISPR-based (hROSA26-SpCas9-NLS-Cas9-SCR7 pyrazine) genome editor.
| Host Cell | DG-75 [D.G.-75] |
| Target | EPHA1 |
| Insert Clone | BCGR-0962CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Mouse genome E-6 |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Tumor-homing peptide tLyp-1/NRP-1 |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 20-2850 |
| Charge (mv) | 10 to 100 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Breast cancer; Lung cancer; Ovarian cancer |
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