This product is a Farage B cell engineering tool based on the Nanoparticles (Dexamethasone/Glucocorticoid receptor) delivery system and CRISPR-based (SHS-321-crRNA:tracrRNA duplex-Cas12-Brefeldin A) genome editor.
| Host Cell | Farage |
| Target | EphA2 |
| Insert Clone | B6CR75 |
| Safe Harbor Sites (SHS) | SHS-321 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Mouse genome E-6 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Dexamethasone/Glucocorticoid receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <1660 |
| Charge (mv) | -5 to -40 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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