This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (LRP-1 targeting peptide/Lipoprotein receptor-related protein-1) delivery system and CRISPR-based (hROSA26-crispr RNA-SpCas9-L755507) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | EphA2 |
| Insert Clone | D2-1A9CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | LRP-1 targeting peptide/Lipoprotein receptor-related protein-1 |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 20-150 |
| Charge (mv) | <-25 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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