This product is a BC-3 B cell engineering tool based on the Gold nanoparticles (SS-Fc/Carcinoembryonic antigen) delivery system and CRISPR-based (SHS-229-sgRNA-Cpf1-RS-1) genome editor.
| Host Cell | BC-3 |
| Target | FBLIM1 |
| Insert Clone | BCG-0356CR |
| Safe Harbor Sites (SHS) | SHS-229 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | SS-Fc/Carcinoembryonic antigen |
| Active Agents | Celastrol |
| Particle Size | 10-50 |
| Charge (mv) | -5 to -75 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Breast cancer; Colon cancer |
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