This product is a Raji B cell engineering tool based on the Sphingosomes (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (hROSA26-huIgH296-Cas12-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | Raji |
| Target | FKBP5 |
| Insert Clone | BCG-0716CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Sphingosomes |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | ESC8 |
| Particle Size | 20-2850 |
| Charge (mv) | -10 to -50 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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