This product is a Ramos (RA 1) B cell engineering tool based on the Solid lipid nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (hROSA26-sgRNA-Cpf1-L755507) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FKBP5 |
| Insert Clone | BCG-2240CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Celastrol |
| Particle Size | 10-1000 |
| Charge (mv) | ≤50 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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