This product is a Ramos (RA 1) B cell engineering tool based on the Dendrimers (MUC1 aptamer/MUC1) delivery system and CRISPR-based (SHS-229-huIgH296-Cpf1-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FLT1 |
| Insert Clone | BG-98E |
| Safe Harbor Sites (SHS) | SHS-229 |
| gRNA | huIgH296 |
| Nuclease | Cpf1 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Dendrimers |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 15-188 |
| Charge (mv) | -2 to -31 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Breast cancer; Lung cancer; Colon cancer |
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