This product is a SU-DHL-6 B cell engineering tool based on the Gold nanoparticles (EpCAM aptamer/Epithelial cell adhesion molecule) delivery system and CRISPR-based (AAVS1-huIgH296-SpCas9-(Z)-4-Hydroxytamoxifen ) genome editor.
| Host Cell | SU-DHL-6 |
| Target | GPC3 |
| Insert Clone | M1E7 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Celastrol |
| Particle Size | 20-3500 |
| Charge (mv) | 15-60 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Breast cancer; Non-small cell lung cancer; Prostate cancer; Liver cancer |
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