This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (Fucoidan/P-selectin) delivery system and CRISPR-based (hROSA26-sgRNA-SpCas9-SCR7 pyrazine ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | IGF1R |
| Insert Clone | M12-G04 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | SpCas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Fucoidan/P-selectin |
| Active Agents | Talazoparib, temozolomide |
| Particle Size | <1000 |
| Charge (mv) | <-25 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Ovarian cancer; Non-small-cell lung cancer; Liver cancer |
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