This product is a BC-2 B cell engineering tool based on the Gold nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (CCR5-huIgH296-SpCas9-RS-1) genome editor.
| Host Cell | BC-2 |
| Target | LAMA4 |
| Insert Clone | HuM 71L5F7 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | RS-1 |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Mouse genome E-7 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | ≤24100 |
| Charge (mv) | < 1 |
| Total Atom Count | -73000000 |
| Surface Atoms (%) | -0.6 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Colon cancer; Glioblastoma; Gastric cancer; Liver cancer |
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