This product is a RPMI 8226 B cell engineering tool based on the Nanoparticles (EGFR mAb/Epidermal Growth Factor Receptor) delivery system and CRISPR-based (AAVS1-sgRNA-Cpf1-RS-1) genome editor.
| Host Cell | RPMI 8226 |
| Target | LRP1 |
| Insert Clone | #2I4C5 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | Thymoquinone |
| Particle Size | <3450 |
| Charge (mv) | <-27 |
| Total Atom Count | -73000000 |
| Surface Atoms (%) | -0.6 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Non-small cell lung cancer; Prostate cancer; Liver cancer; Ovarian cancer |
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