This product is a ST486 B cell engineering tool based on the Liposomes (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-SCR7 pyrazine) genome editor.
| Host Cell | ST486 |
| Target | LRP1 |
| Insert Clone | #2I74C |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Liposomes |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Bortezomib |
| Particle Size | 41-3500 |
| Charge (mv) | −3 to -77 |
| Total Atom Count | -57000000 |
| Surface Atoms (%) | -0.7 |
| Specific Surface Area (m2/g) | -3.6 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Non-small cell lung cancer; Prostate cancer; Liver cancer; Ovarian cancer |
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