This product is a GA-10 B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-RS-1) genome editor.
| Host Cell | GA-10 |
| Target | MSH3 |
| Insert Clone | 2F11-CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Mouse genomeD-4(2) |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Celastrol |
| Particle Size | 10-1000 |
| Charge (mv) | <-25 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Ovarian cancer; Breast cancer |
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