This product is a RPMI 8226 B cell engineering tool based on the Quantum dots (EGFR mAb/Epidermal GrowthFactor Receptor) delivery system and CRISPR-based (AAVS1-SpCas9-NLS-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | RPMI 8226 |
| Target | MSH3 |
| Insert Clone | 8E6CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Mouse genome E-1 |
| Vehicles | Quantum dots |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 1-100 |
| Charge (mv) | 13 to 65 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Ovarian cancer; Breast cancer |
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