This product is a Ramos (RA 1) B cell engineering tool based on the Magnetic nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-289-tracr RNA-Cas9-L755507) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | NAP1L1 |
| Insert Clone | BCGW-0307CR |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 20-2850 |
| Charge (mv) | -25 to -125 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Colorectal cancer; Prostate cancer; Breast cancer |
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