This product is a ST486 B cell engineering tool based on the Nanoparticles (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (AAVS1-crispr RNA-SpCas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | ST486 |
| Target | SNW1 |
| Insert Clone | BCGS-3731CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | Paclitaxel, chlorin e6 |
| Particle Size | ≤900 |
| Charge (mv) | 13 to 65 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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