This product is a RPMI 8226 B cell engineering tool based on the Solid lipid nanoparticles (N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin) delivery system and CRISPR-based (CCR5-tracr RNA-Cas9-Brefeldin A) genome editor.
| Host Cell | RPMI 8226 |
| Target | SNW1 |
| Insert Clone | BCGW-1681CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin |
| Active Agents | Talazoparib, temozolomide |
| Particle Size | 10-50 |
| Charge (mv) | -8 to -55 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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