This product is a CA46 B cell engineering tool based on the Solid lipid nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-SpCas9-NLS-Cas9-Brefeldin A) genome editor.
| Host Cell | CA46 |
| Target | SSB |
| Insert Clone | BCGS-1658CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | DOX |
| Particle Size | <500 |
| Charge (mv) | 13 to 65 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Breast cancer; Colon cancer; Glioblastoma; Gastric cancer; Liver cancer |
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