This product is a BC-2 B cell engineering tool based on the Microbubbles (Transferrin/Transferrin receptor) delivery system and CRISPR-based (CCR5-huIgH296-SpCas9-RS-1 ) genome editor.
| Host Cell | BC-2 |
| Target | Trop2 |
| Insert Clone | RB7-8 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genome E-7 |
| Vehicles | Microbubbles |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | ≤10000 |
| Charge (mv) | <80 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer; Melanoma |
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