This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Tumor-homing peptide tLyp-1/NRP-1) delivery system and CRISPR-based (SHS-227-tracr RNA-Cas9-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | Trop2 |
| Insert Clone | T6-16 |
| Safe Harbor Sites (SHS) | SHS-227 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH-dependent |
| Insertion sites | Mouse genome E-8 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Tumor-homing peptide tLyp-1/NRP-1 |
| Active Agents | Paclitaxel, chlorin e6 |
| Particle Size | 10-50 |
| Charge (mv) | < 0 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer; Melanoma |
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