Human ACE2 antibody pair set for sandwich ELISA useCapture Antibody: Monoclonal IgGDetection Antibody: Unconjugated-Rabbit Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | ACE2 |
| Description | Angiotensin-converting enzyme 2 (ACE2)[5] is an enzyme attached to the cell membranes of cells located in the lungs, arteries, heart, kidney, and intestines.[6][7] ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1-7) (a vasodilator).[8][9][10] ACE2 counters the activity of the related angiotensin-converting enzyme (ACE) by reducing the amount of angiotensin-II and increasing Ang(1-7),[11] making it a promising drug target for treating cardiovascular diseases. ACE2 also serves as the entry point into cells for some coronaviruses, including HCoV-NL63, SARS-CoV, and SARS-CoV-2.[5] The human version of the enzyme can be referred to as hACE2. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone | IV01277 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Clone | RD1012 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, BSA and Azide free |
General Product Property | |
|---|---|
| Product Overview | Human ACE2 antibody pair set for sandwich ELISA use Capture Antibody: Monoclonal IgG Detection Antibody: Unconjugated-Rabbit Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with Human ACE2 . |
| Range | 3.98ng/ml-255ng/ml |
| Research Area | Neuroscience; Signal Transduction; Metabolism |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | ACE2 |
| Full Name | Angiotensin-converting enzyme 2 |
| Background | Angiotensin-converting enzyme 2 (ACE2)[5] is an enzyme attached to the cell membranes of cells located in the lungs, arteries, heart, kidney, and intestines.[6][7] ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1-7) (a vasodilator).[8][9][10] ACE2 counters the activity of the related angiotensin-converting enzyme (ACE) by reducing the amount of angiotensin-II and increasing Ang(1-7),[11] making it a promising drug target for treating cardiovascular diseases. ACE2 also serves as the entry point into cells for some coronaviruses, including HCoV-NL63, SARS-CoV, and SARS-CoV-2.[5] The human version of the enzyme can be referred to as hACE2. |
| Alternative Names | ACE2; ACEH; angiotensin I converting enzyme 2 |
| Gene ID | 59272 |
| Uniprot ID | Q9BYF1 |
| GeneCards | ACE2 |
| HGNC | 13557 |
| Ensembl | ENSG00000130234 |
| OMIM | 300335 |
| Involvement in Disease | Diseases associated with ACE2 include Covid-19 and Severe Acute Respiratory Syndrome. |
| Function | Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis |
For Research Use Only.
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