Toxicity and Safety Evaluation

As a leading Contract Research Organization (CRO) in the world, Creative Biolabs provides a full range of in vivo and in vitro animal toxicity testing services for global customers to support drug discovery and development. Our toxicology department consists of professional teams with extensive experience in toxicology studies, which enable us to determine potential risk factors in early drug development process for our customer's programs. Moreover, all studies from dose design, in-life studies to histology and pathology testing are all conducted in GLP-certified facilities in accordance with the latest guidelines (e.g. EMA, ICH, FDA, WHO).

Importance of Toxicity and Safety Evaluation

Prior to clinical trials, it is necessary to conduct animal toxicity studies to best characterize the potential toxicity of new drug candidates. Generally, the objective of preclinical safety evaluation is to determine the toxic effects with respect to target organs, dose dependency, the relationship between clinical findings and exposure to the compound, and potential reversibility of findings. All these data will be used to provide a safe starting dosage for clinical trials and identify parameters for the clinical monitoring of potential adverse effects.

Toxicity and Safety Evaluation Fig.1 Toxicity and Safety Evaluation.

Our Capabilities

According to FDA and EMA authorities, two mammalian species, including one rodent and one non-rodent species are required for preclinical research. Our experienced toxicologists, pathologists, and veterinary surgeons can design and perform all the toxicity research with many different animal species, which including but not limited to rat, mice, rabbit, guinea pig, dog, mini pig and non-human primates (NHP). In every step of our studies, we will do everything we can to ensure the well-being of experimental animals.

Various of Administration RoutesFig.2 Various of Administration Routes.

Routes of Administration

With a wealth of experience and advanced technology, our professional scientists have the ability to conduct toxicology studies in both conventional and unconventional routes, including:

  • Oral
  • Intravenous
  • Inhalation / Intranasal / Tracheal
  • Intramuscular
  • Subcutaneous
  • Dermal
  • Intraocular / Intravitreal
  • Intra-vaginal
  • Intraduodenal
  • Intrathecal / Intracerebral / Epidural
  • Intraperitoneal

Toxicology Services Available at Creative Biolabs

Creative Biolabs provides comprehensive and one-stop toxicity services covering all important aspects of safety testing. We are committed to helping you identify your most promising drug candidates in preclinical development. If you are interested in the services we can provide, please click the links below.

We will be a good partner with you to make your project a success. To get more information about the service we provide, please feel free to contact us. We will get in touch with you as soon as possible.

For lab research use only.

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Contact Us

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-357-2254
Fax: 1-631-207-8356
UK - Germany

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