Once a compound is identified as “active” through primary screening, more deep characterization of the compound is needed for studying the effect, biophysical characters and cellular activities.

Creative Biolabs provides hit to lead service to help you determine various physical, biological and chemical characters of the hits. Our medicinal chemists deliver the most high-quality lead series to our clients within agreed timelines across a broad range of target classes. This process is speed up by using parallel evaluation methods. By this project, compound scope for further optimization is narrowed. Generally, only two or three leads are left for further optimization.

Our ultimate goal of a hit-to-lead program is to identify most likely leads with improved potency, reduced off-target activities, and physiochemical/metabolic properties suggestive of reasonable in vivo pharmacokinetics. Creative Biolabs makes the final determinations of suitability for subsequent chemical optimization studies.