Once a compound is identified as “active” through screening campaign, more deep characterization is needed for the compound worthy of lead optimization and ultimately clinical development. We employ several computer-based and in vitro assays towards addressing specificity, selectivity, potency for primary hits, hits from SAR expansion, or for compounds that are already part of hit-to-lead or lead optimization efforts in the client's drug discovery programs. Beside regular chemical hits, Creative Biolabs also has extensive experience in characterizing affinity, specificity, epitope and stability for antibody drugs. Our services include:
Cheminformatics-based Characterization
Discovering drugs is still a challenging task for pharmaceutical researchers and companies due to the structural complexity of biomolecules. Cheminformatics is a powerful tool for drug discovery which is able to rectify complex issues occurred in traditional drug discovery system. By cheminformatics, pharmaceutical researchers can better analyze the chemical data, understand complex structural information of chemical compounds, and design new molecules.
Supported by our powerful resources, Creative Biolabs provides comprehensive cheminformatics service. We aim to analyze, simulate, model, and manipulate chemical information and use such information for better drug discovery. We use various cheminformatics tools to help your drug discovery program in a number of ways.
Creative Biolabs provides several tools to support a complete configuration of a product's higher-order structure (HOS), such as secondary and tertiary structure, aggregation and oligomerization. This service is critical to ensure the correct functionality and stability of a compound. The techniques we provide for biophysical characterization including Dynamic Light Scattering (DLS), X-Ray Crystallography, Nuclear Magnetic Resonance (NMR) Spectrometry, Cryo-Electron Microscopy and Mass Spectrometry (MS). Creative Biolabs will help you determine a specific biophysical characterization method according to your specific applications.
Generally, if the structure of a hit is known, the biological effects of the hit can be predicted using other similar compounds' data. Structure-activity relationship (SAR) explores the relationship between a molecule's biological activity and its three-dimensional (3D) structure of the molecule. Quantitative SAR (QSAR) model is regarded as a special case of SAR (when relationships become quantified). Creative Biolabs provides tailored SAR and QSAR model building services to accelerate your drug discovery process. SAR is valuable information in drug discovery and development. It is applied to discover and develop new compounds, as well as assess potential health risks posed by existing compounds.
Antibody Characterization & Analysis
Antibody products have played a major role in the growing biologics drug market. However, the complex nature of antibody products presents a number of unique challenges during their development and manufacture of biopharmaceuticals. Therefore, it is essential to detect, characterize and quantify antibodies as well as to characterize important parameters about structural variants and modifications, affinity and immunogenicity to monitor the stability and safety of the final products. Creative Biolabs is able to offer a wide range of tailored services to meet the quality analysis and high-throughput requirements of antibody therapeutic development projects. These services include antibody structure analysis, post-translational modification analysis, impurity analysis, aggregation analysis, stability analysis, etc.
Creative Biolabs is a long-term expert who provides remarkable antibody related services. For more detailed information, please feel free to contact us or directly sent us an inquiry.
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