As an undisputed global leader in drug discovery, Creative Biolabs offers customized nuclear magnetic resonance (NMR) spectroscopy services for drug discovery to meet all your demands.
Nuclear magnetic resonance spectroscopy, widely named as NMR spectroscopy, is a cogent, lossless technique which utilizes the magnetic performance of certain atomic nuclei. NMR spectroscopy can provide specified message about the dynamics, reaction state, structure, and the chemical state of molecules. The resonance frequency is altered by an intramolecular magnetic field that embraces an atom in a molecule. Therefore, it can give access to particular information of the electronic structure of a molecule. This technique has been used to analyze the intact structural and conformational of complex molecules, and for the quantitative analysis of complex mixtures. In addition, this NMR also mild determinate the reaction rates of chemical systems in the test tube and whole living organisms.
Figure 1. Experimental set-up of the EHQE-NMR spectrometer. (Suefke 2015)
Fragment-based Screening Using NMR Spectroscopy
Fragment-based drug discovery (FBDD) is an approach applied for discovering lead compounds as a portion of the drug discovery. In FBDD, the fragments show remarkable challenges for screening, due to the low binding appetency. NMR spectroscopy has proven to be a powerful tool to handle this issue with many strategies, such as saturation transfer difference spectroscopy, surface plasmon resonance, water-ligand observed via gradient spectroscopy, 19F NMR spectroscopy, and isothermal titration calorimetry.
Biophysical Characterization Using NMR Spectroscopy
The measurement of molecular structure and the characterization of molecular properties display a tremendous challenge for drug discovery. Therefore, several methods are required to roundly characterize the biophysical properties of the drug candidate under various solution conditions. Creative Biolabs can provide unparalleled NMR spectroscopy services for biophysical characterization, to inspect a product's higher-order structure (HOS), including secondary and tertiary structure, oligomerization and aggregation.
Structure Determination Using NMR Spectroscopy
Structure determination is a process of obtaining the three-dimensional positional coordinates of a molecule or biomolecule by an appropriate approach. Structure determination is widely used in a group of targets, not only extremely complex ones, such as protein or DNA, but also very simple molecules, such as diatomic oxygen or nitrogen. Creative Biolabs can offer perfect NMR spectroscopy services for structure determination to analyze the intact structural and conformational of both complex molecules and mixtures.
Our scientists are confident in performing high-quality NMR spectroscopy services. For more detailed information, please feel free to contact us or directly sent us an inquiry.
References
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