Creative Biolabs has established an incomparable and comprehensive target identification and validation platform. With our experienced scientists, our team can provide high-quality functional analysis services with several strategies, including digital imaging techniques, metabolic pathway analysis, and target localization.

Functional analysis is a process to characterize whether a potential target is available for a therapeutic drug for a particular disease. The most common drug targets are proteins, including cell signaling receptors, enzymes, structural proteins, as well as regulatory factors such as protein kinases. In drug discovery, the possibility of a target being druggable is one of the essential factors required to be considered, in other words, a drug must bind to the target and influence its function in a satisfying way. Assessing gene function generally needs particular genetic resources, for example, the transient knockdown of gene expression or stable mutants. Creative Biolabs can perform customized functional analysis services with a series of strategies to meet all your requirements.

Figure  1. miRNA-941 targets identification and functional analysis. (Hu <em>et al.</em> 2012) Figure 1. miRNA-941 targets identification and functional analysis. (Hu et al. 2012)

Digital Imaging

Digital imaging is a technique to produce images, for example, an interior structure or a physical scene of a cell or tissue. When creating a product of digital imaging, the cell usually needs to be managed with gene knockout, antisense technology or RNA interference (RNAi). When the target genes are deleted or disrupted, their expression would be halt, therefore influence the morphology of the cell. Thereby, the variation of morphology can be characterized by digital imaging techniques.

Metabolic Pathway Analysis

Metabolic pathway analysis is discovering and analyzing significant routes in metabolic networks, and it's becoming increasingly essential for evaluating inherent network properties in biochemical reaction networks. There are two primary notions for metabolic pathway analysis: one relies upon elementary flux modes, and the other relies upon extreme pathways.

Target Localization

It's a common view for the drug discovery industry that determining the localization of the drug targets is an essential point in the functional analysis of target identification and validation. Thaw-mount and dry-mount radioautographic is used alone or united with other histochemical approaches for in vivo or in vitro characterizing sites of particular binding and deposition. Besides, receptor radioautography with cellular resolution has turned into an obbligato tool in target localization.

Creative Biolabs has focused on functional analysis for years, with the professional scientists hammering at drug discovery, our team is confident in providing incomparable functional analysis services to meet every client's scientific research or clinical needs. Creative Biolabs provides other various drug discovery services. For more detailed information, please feel free to contact us or directly sent us an inquiry.

References

  1. Hu HY (2012). “Evolution of the human-specific microRNA miR-941”. Nature communications 3, 1145.
  2. Schilling CH (1999). “Metabolic pathway analysis: basic concepts and scientific applications in the post-genomic era”. Biotechnology progress 15(3), 296-303.
  3. Parsons, A. B. (2002). “Yeast genomics and proteomics in drug discovery and target validation”. Progress in cell cycle research 5, 159-166.




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