With vast experience and leading technology platforms, experts in Creative Biolabs are pleased to introduce our impeccable service portfolio of in vitro toxicity test for early lead optimization.
Toxicity assessment poses a crucial part in drug safety profiles, which is the major cause of development termination and market withdraw. Hence, it is essential to evaluate the toxicology potential of drug candidates at an early stage to save time and resource investment. As the evolving technologies of in vitro screening and modeling, various in vitro assays emerge as a rapid, high-efficient and cost-effective choice of estimating drug safety risks recommended by most regulatory authorities. Focused on the increasing need and latest guidelines, Creative Biolabs has brought out this integrated in vitro toxicity testing service using a panel of assays to our global clients, which includes the following features:
Our in vitro toxicity testing service consists of the following aspects:
We conduct cytotoxicity estimation using a panel of cell proliferation and viability tests, which can be sorted into four types by different endpoints:
Compounds interacting with cellular DNA can cause severe gene toxicity, leading to cancer or even inheritable defects. Creative Biolabs employs a full range of genotoxicity liability detection methods under both non-GLP and GLP (OECD-compliant) conditions:
Cardiotoxicity represents one of the major concerns during drug development. Incorporated with iPS/ES-derived cardiomyocytes and in silico techniques, our scientists perform multiple high throughput tests for identifying compounds that potentially interfere with cardiac physiology or functions.
Heavily involved in drug metabolism and detoxification, the liver is the primary victim of drug toxicity. Combined with high content analysis, Creative Biolabs developed two hepatotoxicity evaluating models to minimize the liability of drug-induced liver injuries.
Given the unneglectable adverse effects of ocular toxicity, estimation of ophthalmic hazard is also an essential step required for IND submission. We are able to conduct:
Creative Biolabs is professional in delivering comprehensive in vitro toxicity profiles to help you identify and select the optimal compounds for your drug discovery program.
For more detailed information, please feel free to contact us or directly sent us an inquiry.
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