Lead optimization is a complex, iterative stage in drug discovery and development. It gives better quality of lead molecules. A confirmed lead is used as a starting point, and its toxicity, potency, stability, bioavailability and other pharmacokinetic parameters are studied in order to improve its target specificity, selectivity, and potency. The optimized molecules may subsequently be developed as drug(s).

Creative Biolabs provides world-class lead optimization service. We have well-trained, knowledgeable medicinal chemists and we have many years of experience in drug discovery. We are able to consistently deliver high-quality, accurate drug candidates into investigational new drug (IND) studies within the shortest timeline.

Our integrated ADME, toxicity, and PK studies make this stage highly efficiency. The use of translational biomarkers and radiochemistry make the candidate decision more efficient. With our comprehensive compound data, we enable pharmaceutical companies to overcome synthesis bottlenecks in drug development workflows. Typically two or three lead molecules are optimized in parallel to qualifying a drug candidate.