In Vitro Pharmacodynamics

Pharmacodynamics (PD) is the study of the biochemical, physiologic, and molecular effects of drugs on the body, and involves receptor binding, post-receptor effects, and chemical interactions. It is a study of how the drug affects the organism. It dedicates to determining the dose, duration of the effect. Creative Biolabs provides in vitro methods to determine the PD effects due to changes in dose, dosage form, and dosing regimens. A series of services are available which including but not limited to:

Antibody Function Assay

Antibodies can be used to interfere with microbial invasion of the host, kill the pathogen, neutralize the effects of microbial toxin, and induce the antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-FcRn binding activity. It is not simply the quantity of antibody but also their functional quality that is important for the prevention and clearance of disease. As a leader in the field of antibody, Creative Biolabs provides comprehensive analysis services for complete function evaluation of your therapeutic antibodies. Our services include target binding affinity measurement, neutralization, serum microbicidal antibody (SBA), opsonophagocytic assays and ADCC assay.

Antimicrobial Pharmacodynamics

In recent years, the emerging of fungal/bacterial resistance to antifungal/antibacterial drugs has highlighted the need for establishing clinical correlation with in vitro antimicrobial profiles. Given this, Creative Biolabs' professional drug discovery team provides you a series of broth and agar-based methods for determining microbiological characters, which include in vitro susceptibility testing, dose-response relationship, time-kill analysis, synergistic and antagonistic effects testing, and post antibiotic effect (PAE).

Our services are completely compliance with standards of Clinical and Laboratory Standards Institute (CLSI) and the Subcommittee of European Committee on Antimicrobial Susceptibility Testing (EUCAST). We can determine the minimum inhibitory concentration (MIC), the dosing interval of an antimicrobial agent, the combinational effects of drugs, the relationship of concentration of antimicrobial drugs and microbial growth rate.

Antifungal MOA Determination

Creative Biolabs has always devoted to assisting our worldwide clients for developing the next generation of antifungal therapies. Recent antifungal drugs have many side effects which limit their clinical use. To improve drugs' efficiency and reduce their toxicity, Creative Biolabs proudly presents our exclusive service to investigate the mechanism of action to support drug discovery process.

Creative Biolabs provides several ways to help our customers determine the mode of actions, which include signaling pathway analysis, target deconvolution, and expression profiling. We offer several ways of MOA analysis for antifungals, include interference with fungal cell membrane, interference with fungal cell wall, interference with fungal protein synthesis and interference with fungal nucleic acid synthesis.

Antibacterial MOA Determination

Creative Biolabs provides several ways of MOA analysis for antibacterials to improve drugs' efficiency and reduce their toxicity. We provide several ways of MOA analysis for antibacterials, which include interference with folate biosynthesis, interference with protein synthesis, interference with nucleic acid synthesis and interference with cell wall synthesis.

Creative Biolabs will be with you at every step of your way. For more detailed information, please feel free to contact us or directly sent us an inquiry.

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Tel: 1-631-381-2994
Fax: 1-631-207-8356
Heidenkampsweg 58, 20097 Hamburg, Germany
Tel: 44-207-097-1828

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