Therapeutic Exosomes for Skin Diseases

According to report, exosomes can promote restoration of wound healing and skin regeneration by regulating immune responses, promoting the proliferation and migration of skin cells, and promoting angiogenesis. This provides a new avenue for further realization of cell-free therapy. Creative Biolabs has been committed to exosome-related drug research and can provide the highest quality exosome research services.

Skin and Exosomes

The skin is the outermost structure of the human body, accounting for about 70% of the surface area of human body. The skin is the largest organ that protects the body from external pathogens, sweats, and senses temperature changes. However, the skin is prone to acute and chronic injuries such as burns, dermatitis, etc. Severe skin damage will also leave scars, affecting the patient's physical function and mental health. In addition, with age, skin problems such as pigmentation and fine lines become increasingly prominent. To fight age, many beauty lovers use skin care products that contain various functional ingredients. Stem cell therapy has achieved very fine therapeutic effects. However, the culture and preservation of stem cells are limited. Exosomes are nanoscale vesicle structures derived from cells and are involved in cell-to-cell communication. At present, a large number of studies have found that stem cell-derived exosomes can treat skin diseases and repair skin. A variety of skin care products containing therapeutic exosomes have entered the market.

Fig.1. Diagrammatic representation of the skin structure and the molecular composition of exosomes. (Xiong, 2021)

Therapeutic Exosomes for Skin Diseases

Therapeutic exosomes for skin wound healing can participate in various processes of skin repair and regeneration. These therapeutic exosomes can promote cell proliferation and migration, as well as modulating immune responses. This provides a new avenue for further realization of cell-free therapy.

For skin anti-aging and repairing, exosomes for skin care and exosomes for plastic and cosmetic contain growth factors, anti-inflammatory ingredients, and more. Moreover, these exosomes can easily penetrate the stratum corneum to the dermis to regulate collagen production, thereby improving skin quality. Exosomes can also repair sensitive skin through anti-inflammatory and soothing effects. In addition, based on the repair and regeneration effects of exosomes, exosomes for plastic and cosmetic are also widely used for wound repair after cosmetic surgery.

In the diseased skin microenvironment, therapeutic exosomes can actively regulate and synthesize collagen, thereby promoting the skin to return to normal from the pathological state. Delivery of engineered exosomes loaded with collagen type VII mRNA to Epidermolysis Bullosa (EB) cells stimulates EB cells to produce their own collagen type VII, thereby improving EB. Currently, the therapeutic exosomes for EB has been approved by the FDA to enter Phase I clinical trials to evaluate its safety and efficacy in EB patients.

Creative Biolabs can provide one-stop research services for exosomes and large-scale purification of exosomes. To meet the needs of customers at any time, we have been improving our technology and equipment. If you have exosome discovery needs related to the treatment of skin diseases or cosmetic medicine, please feel free to contact us.

Reference

Xiong, M.; Zhang, Q.; et al. The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics. Pharmacological Research. 2021, 166:105490.

Plant Exosome Isolation