Creative Biolabs offers camel anti-idiotypic antibody (single domain antibody) production service. Our R&D team has enriched experience in the selection of single domain antibody with high affinity and specificity, production, and engineering. Camel is immunized with target antibodies in the forms of whole IgG, scFv, Fab or F(ab’)2 that preserve the antibody activity to develop anti-idiotypic antibodies. Camel’s RNA is extracted and reverse-transcribed to cDNA. With specific primers, genes encoding antibody heavy chains are amplified to creat a cDNA antibody library. It is then efficiently packaged and displayed in M13 phages. High affinity and specificity anti-ID antibodies could be isolated in 10-10 M range. Further affinity maturation and single domain antibody modification services are available in Creative Biolabs. Our professional staffs are professional to convert between different forms of antibody with their knowledge of molecular biology and bioinformatics.
Single domain antibodies are derived from the blood of camelids (llama, alpaca, camel, dromedary, etc). Different from conventional antibodies, the camelid “heavy-chain antibodies” (HCAbs) lack a light chain and are bound to antigen in the nm range with a single domain called VHH due to its small size. Like conventional antibodies, single domain antibodies show well-performed target specificity, high affinity and low inherent toxicity. Like small molecule drugs, they are able to inhibit enzymes and readily access receptor clefts, which is comparable with conventional antibodies.
• Antibody drug pharmacokinetic/pharmacodynamics (PK/PD) studies
• Antibody drug immunogenicity (immune response, IR) studies
• Preclinical research of therapeutic antibodies
• Anti-drug antibodies (ADA) for clinical development
• Controls in ligand binding neutralizing assays
• Controls in antibody blocking assays
• Fast delivery
• High success rate
• Modification of antibody as required
• High specificity and binding affinity
Please click here to see more custom Anti-Idiotypic Antibodies Production Services from Creative Biolabs.